Synergistic effects of bacteriophage cocktail and antibiotics combinations against extensively drug-resistant Acinetobacter baumannii

Synergistic effects of bacteriophage cocktail and antibiotics combinations against extensively drug-resistant Acinetobacter baumannii

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Abstract Background The extensively drug-resistant (XDR) strains of Acinetobacter baumannii have become a major cause of nosocomial infections, increasing morbidity and mortality worldwide.Many different treatments, including Fan Shop - NFL - Hats phage therapy, are attractive ways to overcome the challenges of antibiotic resistance.Methods This study investigates the biofilm formation ability of 30 XDR A.baumannii isolates and the efficacy of a cocktail of four tempetate bacteriophages (SA1, Eve, Ftm, and Gln) and different antibiotics (ampicillin/sulbactam, meropenem, and colistin) in inhibiting and degrading the biofilms of these strains.

Results The majority (83.3%) of the strains exhibited strong biofilm formation.The bacteriophage cocktail showed varying degrees of effectiveness against A.baumannii biofilms, with higher concentrations generally leading to more significant inhibition and degradation rates.

The antibiotics-bacteriophage cocktail combinations also enhanced the inhibition and degradation of biofilms.Conclusion The findings suggested that the bacteriophage cocktail is an effective tool in combating Curling - Bags A.baumannii biofilms, with its efficacy depending on the concentration.Combining antibiotics with the bacteriophage cocktail improved the inhibition and removal of biofilms, indicating a promising strategy for managing A.

baumannii infections.These results contribute to our understanding of biofilm dynamics and the potential of bacteriophage cocktails as a novel therapeutic approach to combat antibiotic-resistant bacteria.